Chapter 1: Introduction: Metastasis as a Therapeutic Target\nRichard J. Ablin and Malcolm D. Mason

Chapter 2: The Natural History of Prostate Cancer\nDavid F. Penson and Peter C. Albertsen

Chapter 3: The Search for Genes Which Influence Prostate Cancer Metastasis: A Moving Target?\nNorman J. Maitland

Chapter 4: Polyunsaturated Fatty Acids and Prostate Cancer Metastasis\nWen G. Jiang

Chapter 5: Role of Prostaglandin Synthesis and Cyclooxygenase-2 in Prostate Cancer and Metastasis\nAlaa F. Badawi

Chapter 6: Cell Cycle Regulation\nRuchi M. Newman and Bruce R. Zetter

Chapter 7: Epithelial-Mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity\nMary J.C. Hendrix, Jun Luo, Elisabeth A. Seftor, Navesh Sharma, Paul M. Heidger\nJr., Michael B. Cohen, Robert Bhatty, Jirapat Chungthapong, Richard E.B. Seftor, and David Lubaroff

Chapter 8: Orthotopic Metastatic Mouse Models of Prostate Cancer\nRobert M. Hoffman

Chapter 9: ß-Catenin, its Binding Partners and Signalling Mechanisms: Implications in Prostate Cancer\nGaynor Davies, Gregory M. Harrison, and Malcolm D. Mason

Chapter 10: Hepatocyte Growth Factor/Scatter Factor and Prostate Cancer Metastasis\nGaynor Davies, Wen G. Jiang, and Malcolm D. Mason

Chapter 11: Matrix Degradation in Prostate Cancer\nMichael J. Wilson and Akhouri A. Sinha

Chapter 12: The Biology of Bone Metastases from Prostate Cancer and the Role of Bisphosphonates\nNoel W. Clarke and Herbert A. Fleisch

Chapter 13: Non-Steroidal Anti-Androgen Use as Part of Combined Androgen Blockade Therapy for Metastatic or Locally Advanced Prostate Cancer: a Review of the Evidence on Efficacy and Toxicity\nMike Shelley, Charles Bennett, Derek Nathan, and Oliver Sartor

Chapter 14: Strategies for the Implementation of Chemotherapy and Radiotherapy\nPaula Scullin, Joe M. O\'Sullivan, and Christopher C. Parker

Chapter 15: Immuno-gene Therapy for Metastatic Prostate Cancer\nTakefumi Satoh, Terry L. Timme, Yehoshua Gdor, Brian J. Miles, Robert J. Amato, Dov Kadmon, and Timothy C. Thompson

Chapter 16: Distilling the Past - Envisioning the Future\nRichard J. Ablin and Malcolm D. Mason