Part I: Introduction§1. The Past, Present and Future of Chemical Risk Assessment§Alice Limonciel§Part II: Systemic Organ Toxicity§2. In Vitro Systems for Hepatotoxicity Testing§Jan G. Hengstler, Seddik Hammad, Ahmed Ghallab, Raymond Reif and Patricio Godoy§3. In Vitro Methods for Cardiotoxicity Testing§Vaibhav Shinde, Umesh Chaudhari, Isaia Sotiriadou, Jürgen Hescheler and Agapios Sachinidis§4. Renal Cell Culture§Paul Jennings, Lydia Aschauer, Anja Wilmes and Gerhard Gstraunthaler§5. Cellular Models for In Vitro Lung Toxicology§Oliver H. Wittekindt§Part III: Neurotoxicity§6. In Vitro Developmental Neurotoxicity Testing: Relevant Models and Endpoints§Anna Bal-Price and Helena T. Hogberg§7. Blood Brain Barrier In Vitro Models and Their Applications in Toxicology§Anaelle Fabulas-Da Costa, Christophe Landry, Lucie Dehouck, Emmanuel Sevin, Marie-Pierre Dehouck, Roméo Cecchelli and Maxime Culot§Part IV: Sensory Organ Models§8. Ocular Toxicity§Chantra Eskes, Erwin van Vliet, Michael Schäffer and Valérie Zuang§9. In Vitro Models for Ototoxic Research§Jochen Schacht and Michael G. Leitner§Part V: Other Organs and Aspects§10. Dermal Toxicity: Skin Sensitization§David Basketter and Silvia Casati§11. Immunotoxicity§Thomas Hartung§12. Reproductive Toxicity§Giovanna Lazzari and Cesare Galli§13. Evaluating Endocrine Disruption In Vitro§Patrick J. Devine§14. Current and Emerging In Vitro Methods for Genotoxicity and Carcinogenicity§Federica Madia, Pascal Phrakonkham, and Raffaella Corvi§Part VI: The Use of Stem Cells§15. Use of Induced Pluripotent Stem Cells in Drug Toxicity Screening§Caroline Rauch, Paul Jennings, and Anja Wilmes§16. Human Stem/Progenitor Cell-Based Assays for Neurodevelopmental Toxicity Testing§Ellen Fritsche§Part VII: Techniques and Markers§17. High Content Imaging Approaches for In Vitro Toxicology§Marianne Uteng, Davide Germano, Kamal Kumar Balavenkatraman, Francois Pognan, and Armin Wolf§18. Application of Omics Technologies to In Vitro Toxicology§Nina V. Balmer, Tyna Dao, Marcel Leist, Kinga Vojnits, Tanja Waldmann, Liang Zhao, Helena T. Hogberg, and Erwin van Vliet§19. Stress Response Pathways§Martin O. Leonard, Alice Limonciel, and Paul Jennings§20. Translational Biomarkers, In Vitro and In Vivo§Anja Wilmes, Alice Limonciel, Martin O. Leonard, and Paul Jennings§Part VIII: Challenges and Considerations§21. Nanotoxicology§Agnieszka Kinsner-Ovaskainen, Pascal Colpo, Jessica Ponti and François Rossi§22. Consideration of Metabolism in In Vitro Cellular Systems§Olavi Pelkonen, Jorma T. Ahokas, Jukka Hakkola, and Miia Turpeinen§23. In Vitro Approaches to Predictive Biokinetics§Bas J. Blaauboer§24. Extrapolating In Vitro Results to Predict Human Toxicity§Nadia Quignot, Jérémy Hamon, and Frederic Y. Bois§25. Considerations in the Development of In Vitro Toxicity Testing Methods Intended for Regulatory Use§Sandra Coecke, Gerard Bowe, Anne Milcamps, Camilla Bernasconi, Ann-Charlotte Bostroem, Gilles Bories, Salvador Fortaner, Jean-Michel Gineste, Varvara Gouliarmou, Ingrid Langezaal, Roman Liska, Emilio Mendoza, Siegfried Morath, Vittorio Reina, Iwona Wilk-Zasadna and Maurice Whelan.§ schovat popis